PhD Studentship in Circadian Rhythms and Ageing in Bristol
Project: CircadiAgeing - Clock excitability, circadian rhythms and healthy ageing Deadline: 3rd December 2025
The Nobel prize was awarded to Drosophila researchers determining the fundamental mechanisms of circadian rhythms conserved from flies to humans. This molecular clock consists of clock genes which are rhythmically expressed in clock neurons controlling the circadian expression of genes encoding ion channels/ receptors that drive daily changes in electrical activity. This membrane clock is vital for synchronising the molecular clock in different clock cells and communicating time-of-day information to the rest of the brain and body. The molecular clock is well understood, but there is a lack of research on the membrane clock. You will help address this crucial knowledge gap and the effect of ageing on both clocks.
The hypothesis you will test is the membrane and molecular clock become synergistically weaker during the lifespan compromising circadian rhythms and the individual’s health during ageing. This predicts that disrupted molecular and membrane clocks significantly contribute to ageing. You will help determine the conserved components and mechanisms of the membrane clock and how it ages.
Find out more about the project and application here