Jobs

Deadline: 26/01/2026 Project title: Chrono-nutrition: turning physiology, behaviour, and psychology into real world interventions Research aims: The overall aims of this project are: 1) better understand how chrono-nutrition (including meal timing, fasting duration and energy restriction) regulate human physiology; and 2) explore how basic laboratory findings can be exploited to improve health through changing eating behaviour in the real world. What you will do: Objective 1. Analyse data sets from ongoing chrono-nutrition research to understand physiological mechanisms. Temporal data sets (blood biomarkers, metabolomics, wearable device data, questionnaire scores) will be analysed to increase understanding of physiological mechanisms that cause health benefits. Objective 2. Design and conduct a novel study of meal timing in a free-living population. Physiological data and behaviour change methods will be used to support real-world changes in eating behaviour. Health outcome measures will be collected along with computerised cognitive tests and self-report measures of sleep, appetite, mental wellbeing. Objective…

Deadline: 18/02/2026 Project title: Mathematical modelling of the cross-talk interactions between the HPA axis and the renin-angiotensin system Hormonal concentrations are regulated by endocrine axes and are the perfect example of complex regulatory systems involving multiple levels of organisation. Endocrine regulation is highly dynamic, with hormone levels exhibiting complex periodic behaviour over short and long timescales (e.g., hourly, daily and monthly rhythms). These systems also exhibit nonlinear responses to perturbations, typically mediated by feedback loops involving multiple components and crosstalk interactions with other endocrine systems. At the same time, endocrine systems exhibit trade-offs between sensitivity and robustness, which allows adaptability to physiological challenges. Importantly, dysregulation of these dynamic processes can lead to disease.

The PhD candidate will leverage multimodal datasets from dynamic hormone profiling (e.g., U-RHYTHM) (3) and biosensors for ambulatory assessment to develop mathematical models of the Hypothalamic-Pituitary-Adrenal axis and its cross-talk interactions with the renin-angiotensin system. The project aims are…

Deadline: 14/01/2026

You will be a part of the "Foundations of Circadian Medicine" joint research consortium which aims to identify the overarching principles that link the circadian clock and pathology in different organs and disease systems, and from this to develop and test evidence-based circadian medicine strategies for clinical application.

This interdisciplinary project (B03) is based at the Institute of Neurobiology in Lübeck (https://www.neurobio.uni-luebeck.de/neurobio) and investigates the mechanistic link between chronotype shifts and metabolic function during adolescence. It tests the hypothesis that circadian rhythm disruption during adolescence alters metabolic setpoints and affects puberty development. The study combines (conditional) transgenic mouse models and physiologic and transcriptomic circadian profiling to assess the effects of rhythm disruption on metabolic homeostasis and puberty development and its long term outcomes. An intervention study aiming at strengthening the circadian system during this critical developmental period will quantify effects on rhythms, metabolism and endocrine functions.

Your tasks:

• Study the…

Deadline: 12/01/2026 We are seeking a highly motivated and talented post-doctoral scientist to join our team for 12 months working full-time on a research project funded by the Kennedy Trust for Rheumatology Research investigating anti-inflammatory responses in Tregs.

The overarching aim of the project is to address the role of the circadian clock protein REV-ERBa in the function of Tregs. REV-ERBa expression will be manipulated using novel tools and the impact on functional activity of Tregs assessed.

More information and application available here.