Postdoctoral Role in Circadian Rhythms of Metabolism During Adolescence in Lübeck
Deadline: 14/01/2026
You will be a part of the "Foundations of Circadian Medicine" joint research consortium which aims to identify the overarching principles that link the circadian clock and pathology in different organs and disease systems, and from this to develop and test evidence-based circadian medicine strategies for clinical application.
This interdisciplinary project (B03) is based at the Institute of Neurobiology in Lübeck (https://www.neurobio.uni-luebeck.de/neurobio) and investigates the mechanistic link between chronotype shifts and metabolic function during adolescence. It tests the hypothesis that circadian rhythm disruption during adolescence alters metabolic setpoints and affects puberty development. The study combines (conditional) transgenic mouse models and physiologic and transcriptomic circadian profiling to assess the effects of rhythm disruption on metabolic homeostasis and puberty development and its long term outcomes. An intervention study aiming at strengthening the circadian system during this critical developmental period will quantify effects on rhythms, metabolism and endocrine functions.
Your tasks:
Study the role of circadian regulation and perturbation during adolescence
Perform endocrine and molecular assays, and animal experiments and analyse transcriptome data
Collaborate closely with clinicians and basic researchers in the Oster and Kühnen (Charité) laboratories
You can find more information here