Jobs

Deadline: 10th December 2025 Dr Miguel Montez leads a five-year Wellcome Trust-funded project to establish his research group and pioneer studies on how the local 3D chromatin structure determines gene regulation and environmental responses. His project is hosted within the well-established and vibrant research environment of Prof Antony Dodd’s group (Head of Department) at the John Innes Centre.

Dr Montez brings deep expertise in studying molecular mechanisms that enable plants to fine-tune gene expression to sense and adapt to the environment. By joining his project, you will become part of an emerging, interdisciplinary, and highly collaborative team that values innovation and curiosity in uncovering new fundamental principles in biology. The Montez group is committed to supporting your scientific development, helping you develop high-impact research and achieve your career goals within a supportive and inspiring environment. The Postdoctoral Researcher will investigate chromatin organisation at a fine scale, with a particular focus on the…

Deadline: 21st November 2025 We are seeking a highly motivated and talented scientist to join our MRC-funded research programme investigating how disruption of the circadian clock impacts energy metabolism and contributes to metabolic disease. You will play a key role in defining how circadian processes in the liver and other tissues regulate lipid metabolism and mitochondrial function, under both normal and perturbed conditions (e.g. dietary or environmental challenges). This exciting project builds on our recent findings (e.g. Downton et al., PNAS; Hayter et al., Nature Communications; West et al., Nature Communications), which demonstrate that circadian disruption—caused by simulated shift work, diet-induced obesity, or chronic inflammation—leads to aberrant liver function and accumulation of harmful lipid species such as ceramides. Working within a vibrant circadian research community in Manchester, you will employ cutting-edge in vivo and in vitro models, advanced physiological phenotyping, and multi-omic and flux metabolomic approaches. You will also collaborate with…

Project: CircadiAgeing - Clock excitability, circadian rhythms and healthy ageing Deadline: 3rd December 2025

The Nobel prize was awarded to Drosophila researchers determining the fundamental mechanisms of circadian rhythms conserved from flies to humans. This molecular clock consists of clock genes which are rhythmically expressed in clock neurons controlling the circadian expression of genes encoding ion channels/ receptors that drive daily changes in electrical activity. This membrane clock is vital for synchronising the molecular clock in different clock cells and communicating time-of-day information to the rest of the brain and body. The molecular clock is well understood, but there is a lack of research on the membrane clock. You will help address this crucial knowledge gap and the effect of ageing on both clocks.

The hypothesis you will test is the membrane and molecular clock become synergistically weaker during the lifespan compromising circadian rhythms and the individual’s health during ageing. This…

The position will be located in the AWI section “Polar Biological Oceanography”, working group “Marine Chronobiology”. The focus of the advertised position is on the investigation of internal clocks and the control of biological rhythms in marine invertebrates (copepod Calanus, bristle worm Platynereis). Specifically, molecular and genetic analyses shall be used to generate an initial functional understanding of the “clock genes” period and timeless. Copepods have a key role in pelagic food webs and they perform daily and seasonal vertical migrations. Platynereis worms use their internal clocks to synchronize their reproduction with the lunar cycle. Find out more and apply here