Dr
@Neurocool @dynamicbrain
0000-0003-3209-5019
Neil Grant, MRC LMB
Nina
Rzechorzek
University of Cambridge
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ORCID ID
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Research Summary
Model Systems
Research Methods
I am a clinical academic and translational neuroscientist studying how circadian biology, sleep, and systemic physiology influence human brain function. My research centres on brain temperature and neural circadian rhythms, including non-invasive neuroimaging approaches to measure spatiotemporal variation in human brain temperature, and the development of human in vitro platforms to study neural circadian multiomics and functional activity.
My current work examines the physiological, temporal, and environmental determinants of brain temperature variation, and how these relationships may change during sleep–wake transitions and in neurological disease. A major aim is to translate fundamental chronobiology into practical biomarkers, precision therapeutic strategies, and clinically useful measures of brain health.
I also work at the interface of neuroscience, digital health, and industry, with interests in wearable sensing, physiological monitoring, AI-enabled analysis, and the translation of emerging technologies into clinical research.
Humans; Non-human mammals excluding rodents; Mice or other rodents; Suprachiasmatic nucleus (SCN); Ex vivo system (other than SCN, derived from humans or other animals); Eukaryotic cells (including primary and transformed cell lines); Stem cells and stem cell-derived platforms; Synthetic; In silico, AI-driven, or theoretical
Quantitative research; Mixed methods research; Basic/fundamental/discovery research; Translational/applied research; Clinical research/clinical trials; Laboratory research; Field research; Non-clinical human studies; In vivo studies or preclinical work with non-human animals; Ex vivo or postmortem studies; In vitro experiments; Biomedical or health research; Physiology (cellular and organismal, including electrophysiology); Sleep research; Psychiatry and mental health research; Neuroscience; Biology; Biochemistry; Biophysics; Molecular biology (including genetics and gene editing); Structural biology; Systems biology; Synthetic biology; Bioinformatics; Imaging
MRC Clinician Scientist, Cambridge | Clinical & Scientific Advisor, SomNyx Ltd | Co-Founder, BioClocks UK | Co-Founder, Cambridge Wearables Innovation Forum | Executive Board Member, Cambridge Precision Health SRI | Advisory Board Member, CircadiAgeing
Lab
Brain Temperature & Neural Circadian Rhythms
Personal web
Resources and Tools
BioClocks UK network and Expert Directory; expertise in human brain-temperature MR spectroscopy and time-resolved neuroimaging; established brain-temperature acquisition protocols and analytical approaches; PER2::LUC x P301S tau mouse; happy to share peer-reviewed published resources
Industry Partnerships
Clinical and scientific advisory work and collaborations spanning sleep technology, wearable sensing, physiological monitoring, neurotechnology, clinical development and translational neuroscience. Partners and collaborators have included SomNyx Ltd, AstraZeneca, bit.bio, Corcept Therapeutics, Dynamic Therapeutics, Empatica, BodyCap, M Dialysis AB, Condor Instruments, TSE Systems, Elson Space Engineering, Condor Instruments, Nexus Football Group, and Altitude Physiology Expeditions (APEX charity).
I am happy to be contacted by
Prospective postdocs; Prospective PhD students; Prospective MSc students; Prospective undergraduate students; Prospective lab technicians or lab managers; Prospective academic collaborators; Prospective industry partners; The media; Funders or charitable organisations; Learned societies; Patient or carer groups; Policymakers or think tanks