Deadline: 10 Feb 2025 Apply here: https://www.imperial.ac.uk/jobs/search-jobs/description/index.php?nPostingId=15296&nPostingTargetId=22523&id=PMMFK026203F3VBQB8NLOV4CQ&LG=UK&languageSelect=UK&mask=ext
Project: Leveraging circadian clocks to prevent Alzheimer’s disease
In this project, you will develop new molecular tools modifying circadian pathways to prevent/ delay Alzheimer’s disease. This project stems from newly established mouse models and clock molecular targets identified in the Brancaccio Lab. You will perform viral delivery of gene therapy viral vectors, behavioural assessment of sleep-wake cycles and cognition, multiplexed live imaging in brain tissue, combinatorial intersectional genetics, and multivariate statistical analysis of time series to validate new chronotherapeutic interventions in Alzheimer’s disease. Further experience with analyses of large ‘OMICS dataset and advanced molecular biology tools in addition to stereotaxic brain surgery and live imaging will be an element of significant strength for this position. Previous knowledge of circadian biology is desirable but not strictly necessary.
What we are looking for
You will be a motivated and organised researcher, excited by the science we do.
You will hold (or be near completion of) a PhD in neuroscience (or related discipline).
Experience of one or more laboratory techniques including live imaging microscopy and advanced techniques of molecular biology (e.g., cloning, viral vector design, construction and production, CRISPR/Cas9 and/or RNAi functional interference
Experience of one or more software packages is essential: MATLAB, ImageJ, SigmaPlot,
Prism, R, as is experience in statistical analysis.
Practical experience with RNAseq, RNA scope, and spatial transcriptomic techniques is highly desirable.
Experience with multivariate statistical analysis of (circadian) time series is highly desirable.
What we can offer you
This role is part of the UK Dementia Research Institute at Imperial College London, located in the Department of Brain Sciences. You will benefit from an active research (and social) environment in the Department of Brain Sciences, with additional research labs in the Sir Michael Uren Hub on the nearby White City Campus. Postdocs in the UK DRI at Imperial enjoy excellent career development opportunities with:
Access to a range of cutting-edge technologies, i.e., real-time live imaging for circadian gene expression and neuronal and glial metabolic function, automated behavioural testing, single cell/nuclei transcriptomics, Imaging Mass Cytometry and computational modelling.
An inclusive and collegial working environment.
Strong national links through the UK DRI with attendance at its annual scientific meeting ‘Connectome’.
The opportunity to continue your career at a world-leading institution and be part of our mission to continue science for humanity.
Grow your career: Gain access to Imperial’s sector-leading dedicated career support for researchers as well as opportunities for promotion and progression
Sector-leading salary and remuneration package (including 39 days off a year and generous pension schemes).
This role is offered on a full time, fixed term basis for 12 months, and is based at Hammersmith Campus.
Please note, Candidates who have not yet been officially awarded their PhD will be appointed as Research Assistant.